- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Propafenone is a class Ic anti-arrhythmic compound that inhibits β-adrenergic receptors, slows Na+ and Ca2+ influx, and decreases overall cellular excitability. Propafenone inhibits Kv1.4 K+ channels and human cardiac two pore-domain (K2P2) K+ channels. Additionally, propafenone inhibits expression of tyrosinase, TRP-1, and TRP-2 and decreases production of cAMP, suppressing melanogenesis in vitro.
Product Info
34183-22-7 |
≥98% |
C21H27NO3 • HCl |
377.91 |
1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1propanone hydrochloride |
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride |
Arythmol; Pronon; Rythmol; Rytmonorm |
171-174°C |
Soluble in basic lower aliphatic alcohols, chloroform and hot water. Slightly soluble in cold water. Insoluble in ether. |
White Crystal Powder |
Shipping and Storage
Ambient |
Ambient |
Downloads
P6852 MSDS PDF |
P6852 Info Sheet PDF |
References
Schmidt C, Wiedmann F, Schweizer PA, et al. Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K(+) (K2P2) channels. Eur J Pharmacol. 2013 Dec 5;721(1-3):237-48. PMID: 24070813.
Huh S, Jung E, Lee J, et al. Mechanisms of melanogenesis inhibition by propafenone. Arch Dermatol Res. 2010 Sep;302(7):561-5. PMID: 20549222.
Tian L, Jiang X, Rasmusson R, et al. Effect of propafenone on Kv1.4 inactivation. J Physiol Biochem. 2006 Dec;62(4):263-70. PMID: 17615952.
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